Herpes simplex virus (HSV) types 1 and 2 are members of the Herpesviridae family, and produce infections that may range from mild stomatitis to disseminated and fatal disease. The presence of IgG-class antibodies to HSV types 1 or 2 indicates previous exposure, and does not necessarily indicate that HSV is the causative agent of an acute illness. Basically, if you test positive for herpes type 1 and negative for 2 that does not mean you don’t have genital herpes. If its you 1st time of getting HSV infection then IGg antibody count might not be present in you blood. Formal name: Herpes Simplex Virus, Type 1 and Type 2. Related tests: TORCH; CSF Analysis. HSV IgG antibody production begins after HSV IgM production.
Unlike IgM, IgG antibodies can be accurately broken down to either HSV-1 or HSV-2. FDA-approved type-specific blood tests available for herpes simplex antibodies. Herpes IgG tests are one type of blood test for the herpes simplex virus (HSV). The two types that herpes blood tests look for are IgG and IgM. Answer: According to 2010 STD Treatment Guidelines, type-specific HSV serologic assays might be useful in the following scenarios: 1) recurrent genital symptoms or atypical symptoms with negative HSV cultures; 2) a clinical diagnosis of genital herpes without lab confirmation; 3) a partner with genital herpes. Question 6: What is your recommendation for treatment of recurrent genital herpes simplex virus 1 (HSV 1)? Answer: IgG tests are recommended in the diagnosis of HSV infections, but only type-specific HSV serologic IgG assays based on HSV glycoprotein G2 and glycoprotein G1 are accurate.
I have had a positive blood test for HSV-2, do not take any suppressive medications and do not have any outbreaks. The presence of antibodies for HSV-2, the most common cause of genital herpes, almost always indicates genital herpes infection with the type 2 virus. These newer tests detect IgG antibodies directed against the cell wall protein specific for HSV-1 or HSV-2. CSF (refer to Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG & IgM (CSF) with Reflex to Type 1 & 2 Glycoprotein G-Specific Ab, IgG, test code 0050364). Herpes simplex is divided into two types; HSV-1 causes primarily mouth, throat, face, eye, and central nervous system infections, whereas HSV-2 causes primarily anogenital infections. Some believe the new IgG test should always be preferred to the old IgM test.
A definition of herpes, what causes herpes, and herpes testing and treatment options. It detects human light chain as well as human heavy chain IgG. This tests for active and previous exposure to the Herpes Simplex Virus. It can also be caused by herpes simplex virus type 1, which is the cause of oral herpes (cold sores on the mouth and lips). Glycoprotein G-2 (gG-2) of herpes simplex virus type 2 (HSV-2) is a viral envelope protein with a feature unique among HSV proteins in the form of cleavage of the gG-2 precursor during processing to a secreted amino-terminal portion (50,51) and to a cell- and virion-associated, heavilyO-glycosylated carboxy-terminal portion that constitutes the mature gG-2 (3, 11, 32, 38, 43, 51). Peroxidase-labeled rabbit anti-mouse IgG (Dako) at a 1:100 dilution was used as conjugate with 4-chloro-1-naphthol as the substrate. Safety Data Sheet Herpes Simplex Virus Type 2 IgG. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Titers of IgG HSV-2 antibody were elevated in the blood.
Herpes Tests Are Not Always Accurate
The finding that herpes simplex virus type 1 (HSV 1) induced IgG Fc receptor binds to all IgG subclasses except IgG 3 prompted an investigation of anti-HSV activity in IgG subclasses from serum and cerebrospinal fluid (CSF) in ten patients with proven or highly probable HSE by means of a monoclonal antibody IgG subclass-specific solid-phase radioimmunoassay (SPRIA).