Didn’t that mean I had antibodies in my blood to HSV-2? A week later, I found out the second guy I had slept with had tested negative for herpes. Is it possible to test negative for both types and then test positive a few months later, even without an outbreak? What about having a false positive test result?. The accurate herpes blood tests–known as type-specific blood tests or serology–detect IgG antibodies. Serum herpes simplex antibodies is a blood test that looks for antibodies to the herpes simplex virus (HSV), including HSV-1 and HSV-2. A negative (normal) test most often means you have not been infected with HSV-1 or HSV-2.