Genital Herpes Screening – STD Information from CDC. In addition, these tests can be expensive; false positive test results may occur in some persons with a low likelihood of infection; and the diagnosis may have adverse psychological effects for some people. Unfortunately, most people who are diagnosed will not be able to determine how long they have had the infection. However, since most cases of genital herpes are caused by HSV-2, a positive result for type-2 antibodies most likely indicates genital herpes. What is the treatment for genital herpes? In most cases where the characteristic signs and symptoms are present, they are sufficient to establish a diagnosis of genital herpes infection, although some evidence exists that because of atypical presentations, missed clinical diagnoses can be high.